Institutes & Centers / Center for Addiction Research / Projects

Active Projects

#20-A0-S2-003671 / UG1DA013035 Title: CTN0100 - Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Phramacotherapy (RDD)
Start: 09-01-2020 / End: 02-28-2026 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T John Grant Sponsor: National Institute on Drug Abuse Grant Amount: $242,292.00

#UG1DA013732-00035 Title: CTN Base: The Ohio Valley Node (OVN) joined NIDA’s Clinical Trials Network (CTN) in September of 2000 as one of the CTN’s second wave of awardees and has been funded continuously since then. Funds in the current 5-year award cycle (6/1/2020 - 2/28/2025) support OVN infrastructure, project development, and support to all OVN performance sites.
Start: 06-01-2020 / End: 02-28-2026 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $4,611,009.0

#UG1DA013732-00037 Title: CTN-0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs): A Pragmatic Randomized Trial Comparing Two Buprenorphine Formulations. (Study sites: Vanderbilt University Medical Center, Nashville, TN; Marshall, Huntington, WV)
Start: 06-01-2018 / End: 02-28-2026 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $9,157,440.00

#UG1DA013732-00041 Title: CTN-0138: Adaptation and Implementation of a Community Pharmacy-Based Prescription Drug Monitoring Pro-gram Risk Assessment Tool
Start: 03-01-2022 / End: 02-28-2026 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $1,176,290.0

#UG1DA013732-00046 Title: CTN-0150: Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME) for pregnant and postpartum persons in MOUD: A pilot randomized trial (TOME trial). (Study sites: Vanderbilt University Medical Center, Nashville, TN; Marshall, Huntington, WV; Magee Women’s Hospital/University of Pittsburgh, Pittsburgh, PA; University of Utah, Salt Lake City, UT; Medical University of South Carolina, Charleston, SC; Gateway Community Services, Inc., Jacksonville, FL)
Start: 03-01-2023 / End: 02-28-2026 Investigators: Winhusen, T PhD Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $443,499.00

#UG1DA013732-00046-A-1 Title: CTN-0080-A-1: Successful Recruitment and Retention in a Randomized Controlled Trial of Pregnant People with Opioid Use Disorder (SUCCESS STUDY)
Start: 03-01-2024 / End: 02-28-2026 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T. Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $333,963.00

#UG1DA013732-00046-A-2 Title: CTN-0080-A-2: Promoting Research with Mothers receiving OUD Treatment; a focus on Equity (PRoMOTE)
Start: 03-01-2024 / End: 02-28-2026 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $298,861.00

#UG1DA013732-00060 Title: CTN-0152: Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the treatment of opioid use disorder: A pragmatic, multi-site, double-blind, Randomized, placebo-controlled, trial (TAB).
Start: 09-15-2024 / End: 02-28-2026 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $7,450,118.00

#UG1DA013732-00061 Title: CTN-0153: Effects of Semaglutide and Tirzepatide on Incidence and Outcomes of Stimulant Use Disorders and Opioid Use Disorder in Real-world Populations: Target Trial Emulation Using Patient Electronic Health Records (GLP-SUD).
Start: 09-15-2024 / End: 02-28-2026 Primary Investigators: T. John John Winhusen Grant Sponsor: National Institute on Drug Abuse (NIDA) Grant Amount: $1,226,367.00

#2UG1DA013732-26 Title: The Ohio Valley Node (OVN) of the Clinical Trials Network
Start: 03-01-2025 / End: 02-29-2032 Primary Investigators: T. John John Winhusen Investigators: Burlew, Ann Kathleen Hoard; Montgomery, LaTrice; Winhusen, T. John Grant Sponsor: National Institute on Drug Abuse Grant Amount: $12,351,691.00

#60071380 OSU (UM1DA049417 NIH NIDA) Title: Optimizing HEALing in Ohio Communities (OHIO)
Start: 04-17-2019 / End: 03-31-2026 Primary Investigators: T. John John Winhusen Investigators: Winhusen, T John; Brown, Jennifer PhD; Lyons, Michael MD; McMullan, Jason Grant Sponsor: National Institute on Drug Abuse Grant Amount: $15,781,558.00

#Early Intervention Program (EIP) 2025-26 Title: HIV Prevention Activities Grant
Start: 06-01-2025 / End: 05-31-2026 Primary Investigators: Richard J. Ryan Investigators: Ryan, Richard Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $210,000.00 (level: Federal)

#UC-EHE_Ending the HIV Pandemic FY25-26 Title: Ending the HIV Pandemic
Start: 06-01-2025 / End: 05-31-2026 Primary Investigators: Richard J. Ryan Investigators: Ryan, Richard Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $155,000.00 (level: Federal)

#K01Da054339 Title: Circuit-Selective Astroglial Plasticity During Opioid Relapse
Start: 08-01-2022 / End: 07-31-2027 Primary Investigators: Anna Katherine Kruyer Investigators: Anna Kruyer Grant Sponsor: National Institute on Drug Abuse Grant Amount: $964,010.00 (level: National)

#R01AA030486 Title: Therapeutic and mechanistic significance of altered metabolism of HIV medicines by alcohol- or alcohol/synthetic opioid combination
Start: 09-10-2022 / End: 07-31-2027 Investigators: ; Blackard, Jason; Brown, Jennifer; Robertson, Jaime; Welge, Jeffrey; Yan, Bingfang Grant Sponsor: National Institute on Alcohol Abuse and Alcoholism Grant Amount: $721,672.00 (level: Federal)

#315660 / H79TI084035 Title: FY 2021 Screening, Brief Intervention and Referral to Treatment (SBIRT)
Start: 09-30-2021 / End: 09-29-2026 Primary Investigators: Shauna P Acquavita Investigators: Acquavita, Shauna Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $33,878.00 (level: Federal)

#H79TI085997 Title: Alternatives to opioids for pain in the emergency department: Implementing Integrative Health approaches and expanding local nerve block initiatives
Start: 09-30-2023 / End: 09-29-2026 Investigators: Freiermuth, Caroline; Ryan, Richard Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $478,958.00 (level: Federal)

Recently Completed Projects

#R33DA048439 Title: PHASE II-Omics analysis of HIV during synthetic opioid exposure
Start: 2022-01-01 / End: 2025-12-31 Primary Investigators: Blackard, Jason PhD Investigators: Brown, Jennifer PhD; Medvedovic, Mario PHD; Sherman, Kenneth MD,PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $1,220,730.00 (level: Federal)

#Early Intervention Program (EIP) 2024-25 Title: HIV Prevention Activities Grant
Start: 2024-08-01 / End: 2025-05-31 Primary Investigators: Ryan, Richard MD Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $167,000.00 (level: Federal)

#312397 / R01DA051895 Title: Role of Siglec-1 in HIV Interactions with Microglia and Astrocytes
Start: 2020-07-15 / End: 2025-04-30 Primary Investigators: Blackard, Jason PhD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $70,692.65 (level: Federal)

#UG1DA013732 Title: Ohio Valley Node-Network (OVNN) of the NIDA Clinical Trials Network
Start: 2015-09-01 / End: 2025-02-28 Primary Investigators: Winhusen, T. John PHD Investigators: Elder, Nancy MD Grant Sponsor: National Institute on Drug Abuse Grant Amount: $16,108,823.00 (level: Federal)

#ODMHA 2300761 (SAMHSA H79TI085753) Title: State Opioid and Stimulant Response (SOS) 3.0
Start: 2022-09-30 / End: 2024-09-29 Primary Investigators: Ryan, Richard MD Investigators: Freiermuth, Caroline MD Grant Sponsor: Substance Abuse & Mental Health Services Administration Grant Amount: $300,000.00 (level: Federal)

#U01DA050330 Title: IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody
Start: 2019-09-15 / End: 2024-07-31 Primary Investigators: Norman, Andrew PhD Investigators: Amlal, Hassane PhD; Kirley, Terence PhD; Rubinstein, Jack MD; Webster, Rose Grant Sponsor: National Institute on Drug Abuse Grant Amount: $4,056,896.00 (level: Federal)

#Early Intervention Program (EIP) 2023 Title: HIV Prevention Activities Grant
Start: 2023-01-01 / End: 2024-07-31 Primary Investigators: Ryan, Richard MD Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $298,334.00 (level: Federal)

#U01DA050330 Title: IND-Enabling Pre-Clinical Studies to Accelerate the Clinical Development of a Humanized Anti-Cocaine Monoclonal Antibody
Start: 2019-09-15 / End: 2024-07-31 Primary Investigators: Norman, Andrew PhD Investigators: Amlal, Hassane PhD; Kirley, Terence PhD; Rubinstein, Jack MD; Webster, Rose Grant Sponsor: National Institute on Drug Abuse (level: Federal)

#R21AI165171 Title: Biomarkers of Replication and Injury in HBV/HIV Coinfection
Start: 2021-07-12 / End: 2024-06-30 Primary Investigators: Sherman, Kenneth MD,PhD Investigators: Blackard, Jason PhD Grant Sponsor: National Institute of Allergy and Infectious Diseases Grant Amount: $443,976.00 (level: Federal)

#2023-110901 / 6NU38OT000306-05-01 Title: ED Based Substance Use Navigation - Advancing the Evidence
Start: 2023-10-01 / End: 2024-06-30 Primary Investigators: Freiermuth, Caroline MD Investigators: Ryan, Richard MD Grant Sponsor: Centers for Disease Control and Prevention Grant Amount: $99,708.53 (level: Federal)

#R13AI071925 Title: HIV and Liver Disease Conference
Start: 2021-04-12 / End: 2024-03-31 Primary Investigators: Sherman, Kenneth MD,PhD Grant Sponsor: National Institute of Allergy and Infectious Diseases Grant Amount: $65,001.00 (level: Federal)