Riccardo Barrile

Abedi, Kimia; Sissoko, Cheick; Pun, Sirjana; Kappagantula, Sumedha; Zucca, Beatrice; Barrile, Riccardo 2026. Modeling glioblastoma niche-by-niche: recent advancements in bioengineering of organotypic models of glioblastoma for precision medicine. Biofabrication, 18 3,

Bardhan, Mainak; Paul, Samanta; Pun, Sirjana; Aryal, Manish Raj; Claudio, Pier Paolo; Binder, Jason; Barrile, Riccardo; Krummel, Daniel A Pomeranz 2026. Integrating ex vivo platforms with AI to guide glioblastoma treatment. Journal of neuro-oncology, 179 2,

Poling, Holly M; Noël, Théo; Singh, Akaljot; Fisher, Garrett W; Thorner, Konrad; Chaturvedi, Praneet; Nattamai, Kalpana; Srivastava, Kalpana; Batie, Matthew R; Hausfeld, Taylor; Pitstick, Amy L; Brown, Nicole E; Ménoret, Séverine; Anegon, Ignacio; Barrile, Riccardo; Mayhew, Christopher N; Takebe, Takanori; Wells, James M; Helmrath, Michael A; Mahe, Maxime M 2026. Large-scale and innervated functional human gut tissues for transplantation via transient spheroid confinement. Nature biomedical engineering, ,

Sissoko, Cheick; Spitz, Sarah; Zhang, Zhengyu; Abedi, Kimia; Kamm, Roger D; Barrile, Riccardo 2026. Engineering the blood-brain barrier on chip: advances in preclinical drug penetration and disease modeling. Advanced drug delivery reviews, 234 , 115881

Barrile, Riccardo; Kasendra, Magdalena 2025. Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches. Cell stem cell, 32 5, 678-680

Poling, Holly M; Noël, Théo; Singh, Akaljot; Fisher, Garrett W; Thorner, Konrad; Chaturvedi, Praneet; Nattamai, Kalpana; Srivastava, Kalpana; Batie, Matthew R; Hausfeld, Taylor; Pitstick, Amy L; Ménoret, Séverine; Anegon, Ignacio; Barrile, Riccardo; Mayhew, Christopher N; Takebe, Takanori; Wells, James M; Helmrath, Michael A; Mahe, Maxime M 2025. Engineering Large-Scale and Innervated Functional Human Gut for Transplantation. bioRxiv : the preprint server for biology, ,

Soussi, Fadoua El Abdellaoui; Brusilovsky, Michael; Buck, Emma; Bacon, W Clark; Dadgar, Sina; Fullerton, Aaron; Durban, Victoria Marsh; Barrile, Riccardo; Helmrath, Michael A; Takebe, Takanori; Roth, Adrian; Kasendra, Magdalena 2025. Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 12 43, e08584

Bhattacharya, Debanjan; Barrile, Riccardo; Toukam, Donatien Kamdem; Gawali, Vaibhavkumar S; Kallay, Laura; Ahmed, Taukir; Brown, Hawley; Rezvanian, Sepideh; Karve, Aniruddha; Desai, Pankaj B; Medvedovic, Mario; Wang, Kyle; Ionascu, Dan; Harun, Nusrat; Vallabhapurapu, Subrahmanya; Wang, Chenran; Qi, Xiaoyang; Baschnagel, Andrew M; Kritzer, Joshua A; Cook, James M; Pomeranz Krummel, Daniel A; Sengupta, Soma 2024. GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors. Cancers, 16 18,

Boylin, Katherine; Aquino, Grace V; Purdon, Michael; Abedi, Kimia; Kasendra, Magdalena; Barrile, Riccardo 2024. Basic models to advanced systems: harnessing the power of organoids-based microphysiological models of the human brain. Biofabrication, 16 3,

Poling, Holly M; Brown, Nicole; Wells, James M; Barrile, Riccardo; Helmrath, Michael A; Mahe, Maxime M 2024. Mechanical stimulation promotes human intestinal villus morphogenesis in vivo. Biophysics reviews, 5 3, 032102

Pun, Sirjana; Prakash, Anusha; Demaree, Dalee; Krummel, Daniel Pomeranz; Sciumè, Giuseppe; Sengupta, Soma; Barrile, Riccardo 2024. Rapid Biofabrication of an Advanced Microphysiological System Mimicking Phenotypical Heterogeneity and Drug Resistance in Glioblastoma. Advanced healthcare materials, 13 30, e2401876

Kerns, Jordan S; Belgur, Chaitra; Kanellias, Marianne; Manatakis, Dimitris V; Barrile, Riccardo; Tien-Street, Will; Ewart, Lorna; Gjorevski, Nikolche; Cabon, Lauriane 2023. Safety Profiling of Tumor-targeted T Cell-Bispecific Antibodies with Alveolus Lung- and Colon-on-Chip. Bio-protocol, 13 1,

Sawyer, Russell P; Pun, Sirjana; Karkoska, Kristine A; Clendinen, Cherita A; DeBaun, Michael R; Gutmark, Ephraim; Barrile, Riccardo; Hyacinth, Hyacinth I 2022. Effect of Blood Transfusion on Cerebral Hemodynamics and Vascular Topology Described by Computational Fluid Dynamics in Sickle Cell Disease Patients. Brain sciences, 12 10,

Kerns, S Jordan; Belgur, Chaitra; Petropolis, Debora; Kanellias, Marianne; Barrile, Riccardo; Sam, Johannes; Weinzierl, Tina; Fauti, Tanja; Freimoser-Grundschober, Anne; Eckmann, Jan; Hage, Carina; Geiger, Martina; Ng, Patrick Ray; Tien-Street, William; Manatakis, Dimitris V; Micallef, Virginie; Gerard, Regine; Bscheider, Michael; Breous-Nystrom, Ekaterina; Schneider, Anneliese; Giusti, Anna Maria; Bertinetti-Lapatki, Cristina; Grant, Heather Shannon; Roth, Adrian B; Hamilton, Geraldine A; Singer, Thomas; Karalis, Katia; Moisan, Annie; Bruenker, Peter; Klein, Christian; Bacac, Marina; Gjorevski, Nikolce; Cabon, Lauriane 2021. Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies. eLife, 10 ,

Pun, Sirjana; Haney, Li Cai; Barrile, Riccardo 2021. Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions. Micromachines, 12 10,

Varone, Antonio; Nguyen, Justin Ke; Leng, Lian; Barrile, Riccardo; Sliz, Josiah; Lucchesi, Carolina; Wen, Norman; Gravanis, Achille; Hamilton, Geraldine A; Karalis, Katia; Hinojosa, Christopher D 2021. A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it. Biomaterials, 275 , 120957

Thacker, Vivek V; Dhar, Neeraj; Sharma, Kunal; Barrile, Riccardo; Karalis, Katia; McKinney, John D 2020. A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth. eLife, 9 ,

Jang, Kyung-Jin; Otieno, Monicah A; Ronxhi, Janey; Lim, Heng-Keang; Ewart, Lorna; Kodella, Konstantia R; Petropolis, Debora B; Kulkarni, Gauri; Rubins, Jonathan E; Conegliano, David; Nawroth, Janna; Simic, Damir; Lam, Wing; Singer, Monica; Barale, Erio; Singh, Bhanu; Sonee, Manisha; Streeter, Anthony J; Manthey, Carl; Jones, Barry; Srivastava, Abhishek; Andersson, Linda C; Williams, Dominic; Park, Hyoungshin; Barrile, Riccardo; Sliz, Josiah; Herland, Anna; Haney, Suzzette; Karalis, Katia; Ingber, Donald E; Hamilton, Geraldine A 2019. Reproducing human and cross-species drug toxicities using a Liver-Chip. Science translational medicine, 11 517,

Nawroth, Janna C; Barrile, Riccardo; Conegliano, David; van Riet, Sander; Hiemstra, Pieter S; Villenave, Remi 2019. Stem cell-based Lung-on-Chips: The best of both worlds? Advanced drug delivery reviews, 140 , 12-32

Vatine, Gad D; Barrile, Riccardo; Workman, Michael J; Sances, Samuel; Barriga, Bianca K; Rahnama, Matthew; Barthakur, Sonalee; Kasendra, Magdalena; Lucchesi, Carolina; Kerns, Jordan; Wen, Norman; Spivia, Weston R; Chen, Zhaohui; Van Eyk, Jennifer; Svendsen, Clive N 2019. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. Cell stem cell, 24 6, 995-1005.e6

Barrile, Riccardo; van der Meer, Andries D; Park, Hyoungshin; Fraser, Jacob P; Simic, Damir; Teng, Fang; Conegliano, David; Nguyen, Justin; Jain, Abhishek; Zhou, Mimi; Karalis, Katia; Ingber, Donald E; Hamilton, Geraldine A; Otieno, Monicah A 2018. Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems. Clinical pharmacology and therapeutics, 104 6, 1240-1248

Jain, A; Barrile, R; van der Meer, A D; Mammoto, A; Mammoto, T; De Ceunynck, K; Aisiku, O; Otieno, M A; Louden, C S; Hamilton, G A; Flaumenhaft, R; Ingber, D E 2018. Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. Clinical pharmacology and therapeutics, 103 2, 332-340

Jain, Abhishek; van der Meer, Andries D; Papa, Anne-Laure; Barrile, Riccardo; Lai, Angela; Schlechter, Benjamin L; Otieno, Monicah A; Louden, Calvert S; Hamilton, Geraldine A; Michelson, Alan D; Frelinger, Andrew L; Ingber, Donald E 2016. Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium. Biomedical microdevices, 18 4, 73

Barrile, Riccardo; Kasendra, Magdalena; Rossi-Paccani, Silvia; Merola, Marcello; Pizza, Mariagrazia; Baldari, Cosima; Soriani, Marco; Aricò, Beatrice 2015. Neisseria meningitidis subverts the polarized organization and intracellular trafficking of host cells to cross the epithelial barrier. Cellular microbiology, 17 9, 1365-75

Bozza, Giuseppe; Capitani, Mirco; Montanari, Paolo; Benucci, Barbara; Biancucci, Marco; Nardi-Dei, Vincenzo; Caproni, Elena; Barrile, Riccardo; Picciani, Benedetta; Savino, Silvana; Aricò, Beatrice; Rappuoli, Rino; Pizza, Mariagrazia; Luini, Alberto; Sallese, Michele; Merola, Marcello 2014. Role of ARF6, Rab11 and external Hsp90 in the trafficking and recycling of recombinant-soluble Neisseria meningitidis adhesin A (rNadA) in human epithelial cells. PloS one, 9 10, e110047

Casellato, Alessandro; Rossi Paccani, Silvia; Barrile, Riccardo; Bossi, Fleur; Ciucchi, Laura; Codolo, Gaia; Pizza, Mariagrazia; Aricò, Beatrice; de Bernard, Marina 2014. The C2 fragment from Neisseria meningitidis antigen NHBA increases endothelial permeability by destabilizing adherens junctions. Cellular microbiology, 16 6, 925-37

Kasendra, Magdalena; Barrile, Riccardo; Leuzzi, Rosanna; Soriani, Marco 2014. Clostridium difficile toxins facilitate bacterial colonization by modulating the fence and gate function of colonic epithelium. The Journal of infectious diseases, 209 7, 1095-104

Montanari, Paolo; Bozza, Giuseppe; Capecchi, Barbara; Caproni, Elena; Barrile, Riccardo; Norais, Nathalie; Capitani, Mirco; Sallese, Michele; Cecchini, Paola; Ciucchi, Laura; Gao, Zhenai; Rappuoli, Rino; Pizza, Mariagrazia; Aricò, Beatrice; Merola, Marcello 2012. Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion. Cellular microbiology, 14 3, 368-85

Ng P.;Belgur C.;Barthakur S.;van der Meer A.;Hamilton G.;Barrile R. 10-01-2019. Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis Current Opinion in Toxicology, 17 , 1-8