Contact Information Childrens Hospital Bldg R Office 513-556-3642 Email huppersy@ucmail.uc.edu Peer Reviewed Publications Miethke, Alexander G; Huppert, Stacey S 2013. Fishing for biliary atresia susceptibility genes. Gastroenterology, 144 5, 878-81Hang, Brian I; Thorne, Curtis A; Robbins, David J; Huppert, Stacey S; Lee, Laura A; Lee, Ethan 2012. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorganic & medicinal chemistry, 20 6, 1869-77Humphreys, Ryan; Zheng, Wei; Prince, Lawrence S; Qu, Xianghu; Brown, Christopher; Loomes, Kathleen; Huppert, Stacey S; Baldwin, Scott; Goudy, Steven 2012. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Human molecular genetics, 21 6, 1374-83Murphy, Andrew J; de Caestecker, Christian; Pierce, Janene; Boyle, Scott C; Ayers, Gregory D; Zhao, Zhiguo; Libes, Jaime M; Correa, Hernan; Walter, Teagan; Huppert, Stacey S; Perantoni, Alan O; de Caestecker, Mark P; Lovvorn, Harold N 2012. CITED1 expression in liver development and hepatoblastoma. Neoplasia (New York, N.Y.), 14 12, 1153-63Vanderpool, Charles; Sparks, Erin E; Huppert, Kari A; Gannon, Maureen; Means, Anna L; Huppert, Stacey S 2012. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology (Baltimore, Md.), 55 1, 233-43Walter, Teagan J; Sparks, Erin E; Huppert, Stacey S 2012. 3-dimensional resin casting and imaging of mouse portal vein or intrahepatic bile duct system. Journal of visualized experiments : JoVE, 68, e4272Huppert, Stacey S 2011. A new set of classifications for ductal plate malformations. Hepatology (Baltimore, Md.), 53 6, 1795-7Sparks, Erin E; Perrien, Daniel S; Huppert, Kari A; Peterson, Todd E; Huppert, Stacey S 2011. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Disease models & mechanisms, 4 3, 359-67Thorne, Curtis A; Lafleur, Bonnie; Lewis, Michelle; Hanson, Alison J; Jernigan, Kristin K; Weaver, David C; Huppert, Kari A; Chen, Tony W; Wichaidit, Chonlarat; Cselenyi, Christopher S; Tahinci, Emilios; Meyers, Kelly C; Waskow, Emily; Orton, Darren; Salic, Adrian; Lee, Laura A; Robbins, David J; Huppert, Stacey S; Lee, Ethan 2011. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. Journal of biomolecular screening, 16 9, 995-1006Sparks, Erin E; Huppert, Kari A; Brown, Melanie A; Washington, M Kay; Huppert, Stacey S 2010. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (Baltimore, Md.), 51 4, 1391-400Huppert, Stacey S; Magnuson, Mark A 2009. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Science signaling, 2 83, pe50Knutson, Sarah K; Chyla, Brenda J; Amann, Joseph M; Bhaskara, Srividya; Huppert, Stacey S; Hiebert, Scott W 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. The EMBO journal, 27 7, 1017-28Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon; Huppert, Stacey; Liu, Zhenyi; Korving, Jeroen; van den Born, Maaike; Stappenbeck, Thaddeus; Wu, Yumei; Clevers, Hans; Kopan, Raphael 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England), 134 3, 535-44Chandu, Dilip; Huppert, Stacey S; Kopan, Raphael 2006. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of neurochemistry, 96 1, 228-35Huppert, Stacey S; Ilagan, Ma Xenia G; De Strooper, Bart; Kopan, Raphael 2005. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental cell, 8 5, 677-88Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood, 104 10, 3097-105Nichols, Amy M; Pan, Yonghua; Herreman, An; Hadland, Brandon K; De Strooper, Bart; Kopan, Raphael; Huppert, Stacey S 2004. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000), 40 1, 40-4
Peer Reviewed Publications Miethke, Alexander G; Huppert, Stacey S 2013. Fishing for biliary atresia susceptibility genes. Gastroenterology, 144 5, 878-81Hang, Brian I; Thorne, Curtis A; Robbins, David J; Huppert, Stacey S; Lee, Laura A; Lee, Ethan 2012. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorganic & medicinal chemistry, 20 6, 1869-77Humphreys, Ryan; Zheng, Wei; Prince, Lawrence S; Qu, Xianghu; Brown, Christopher; Loomes, Kathleen; Huppert, Stacey S; Baldwin, Scott; Goudy, Steven 2012. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Human molecular genetics, 21 6, 1374-83Murphy, Andrew J; de Caestecker, Christian; Pierce, Janene; Boyle, Scott C; Ayers, Gregory D; Zhao, Zhiguo; Libes, Jaime M; Correa, Hernan; Walter, Teagan; Huppert, Stacey S; Perantoni, Alan O; de Caestecker, Mark P; Lovvorn, Harold N 2012. CITED1 expression in liver development and hepatoblastoma. Neoplasia (New York, N.Y.), 14 12, 1153-63Vanderpool, Charles; Sparks, Erin E; Huppert, Kari A; Gannon, Maureen; Means, Anna L; Huppert, Stacey S 2012. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology (Baltimore, Md.), 55 1, 233-43Walter, Teagan J; Sparks, Erin E; Huppert, Stacey S 2012. 3-dimensional resin casting and imaging of mouse portal vein or intrahepatic bile duct system. Journal of visualized experiments : JoVE, 68, e4272Huppert, Stacey S 2011. A new set of classifications for ductal plate malformations. Hepatology (Baltimore, Md.), 53 6, 1795-7Sparks, Erin E; Perrien, Daniel S; Huppert, Kari A; Peterson, Todd E; Huppert, Stacey S 2011. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Disease models & mechanisms, 4 3, 359-67Thorne, Curtis A; Lafleur, Bonnie; Lewis, Michelle; Hanson, Alison J; Jernigan, Kristin K; Weaver, David C; Huppert, Kari A; Chen, Tony W; Wichaidit, Chonlarat; Cselenyi, Christopher S; Tahinci, Emilios; Meyers, Kelly C; Waskow, Emily; Orton, Darren; Salic, Adrian; Lee, Laura A; Robbins, David J; Huppert, Stacey S; Lee, Ethan 2011. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. Journal of biomolecular screening, 16 9, 995-1006Sparks, Erin E; Huppert, Kari A; Brown, Melanie A; Washington, M Kay; Huppert, Stacey S 2010. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (Baltimore, Md.), 51 4, 1391-400Huppert, Stacey S; Magnuson, Mark A 2009. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Science signaling, 2 83, pe50Knutson, Sarah K; Chyla, Brenda J; Amann, Joseph M; Bhaskara, Srividya; Huppert, Stacey S; Hiebert, Scott W 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. The EMBO journal, 27 7, 1017-28Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon; Huppert, Stacey; Liu, Zhenyi; Korving, Jeroen; van den Born, Maaike; Stappenbeck, Thaddeus; Wu, Yumei; Clevers, Hans; Kopan, Raphael 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England), 134 3, 535-44Chandu, Dilip; Huppert, Stacey S; Kopan, Raphael 2006. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of neurochemistry, 96 1, 228-35Huppert, Stacey S; Ilagan, Ma Xenia G; De Strooper, Bart; Kopan, Raphael 2005. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental cell, 8 5, 677-88Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood, 104 10, 3097-105Nichols, Amy M; Pan, Yonghua; Herreman, An; Hadland, Brandon K; De Strooper, Bart; Kopan, Raphael; Huppert, Stacey S 2004. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000), 40 1, 40-4
Miethke, Alexander G; Huppert, Stacey S 2013. Fishing for biliary atresia susceptibility genes. Gastroenterology, 144 5, 878-81Hang, Brian I; Thorne, Curtis A; Robbins, David J; Huppert, Stacey S; Lee, Laura A; Lee, Ethan 2012. Screening for small molecule inhibitors of embryonic pathways: sometimes you gotta crack a few eggs. Bioorganic & medicinal chemistry, 20 6, 1869-77Humphreys, Ryan; Zheng, Wei; Prince, Lawrence S; Qu, Xianghu; Brown, Christopher; Loomes, Kathleen; Huppert, Stacey S; Baldwin, Scott; Goudy, Steven 2012. Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Human molecular genetics, 21 6, 1374-83Murphy, Andrew J; de Caestecker, Christian; Pierce, Janene; Boyle, Scott C; Ayers, Gregory D; Zhao, Zhiguo; Libes, Jaime M; Correa, Hernan; Walter, Teagan; Huppert, Stacey S; Perantoni, Alan O; de Caestecker, Mark P; Lovvorn, Harold N 2012. CITED1 expression in liver development and hepatoblastoma. Neoplasia (New York, N.Y.), 14 12, 1153-63Vanderpool, Charles; Sparks, Erin E; Huppert, Kari A; Gannon, Maureen; Means, Anna L; Huppert, Stacey S 2012. Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology (Baltimore, Md.), 55 1, 233-43Walter, Teagan J; Sparks, Erin E; Huppert, Stacey S 2012. 3-dimensional resin casting and imaging of mouse portal vein or intrahepatic bile duct system. Journal of visualized experiments : JoVE, 68, e4272Huppert, Stacey S 2011. A new set of classifications for ductal plate malformations. Hepatology (Baltimore, Md.), 53 6, 1795-7Sparks, Erin E; Perrien, Daniel S; Huppert, Kari A; Peterson, Todd E; Huppert, Stacey S 2011. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Disease models & mechanisms, 4 3, 359-67Thorne, Curtis A; Lafleur, Bonnie; Lewis, Michelle; Hanson, Alison J; Jernigan, Kristin K; Weaver, David C; Huppert, Kari A; Chen, Tony W; Wichaidit, Chonlarat; Cselenyi, Christopher S; Tahinci, Emilios; Meyers, Kelly C; Waskow, Emily; Orton, Darren; Salic, Adrian; Lee, Laura A; Robbins, David J; Huppert, Stacey S; Lee, Ethan 2011. A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopus egg extracts. Journal of biomolecular screening, 16 9, 995-1006Sparks, Erin E; Huppert, Kari A; Brown, Melanie A; Washington, M Kay; Huppert, Stacey S 2010. Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (Baltimore, Md.), 51 4, 1391-400Huppert, Stacey S; Magnuson, Mark A 2009. New complexity in differentiating stem cells toward hepatic and pancreatic fates. Science signaling, 2 83, pe50Knutson, Sarah K; Chyla, Brenda J; Amann, Joseph M; Bhaskara, Srividya; Huppert, Stacey S; Hiebert, Scott W 2008. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. The EMBO journal, 27 7, 1017-28Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon; Huppert, Stacey; Liu, Zhenyi; Korving, Jeroen; van den Born, Maaike; Stappenbeck, Thaddeus; Wu, Yumei; Clevers, Hans; Kopan, Raphael 2007. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England), 134 3, 535-44Chandu, Dilip; Huppert, Stacey S; Kopan, Raphael 2006. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. Journal of neurochemistry, 96 1, 228-35Huppert, Stacey S; Ilagan, Ma Xenia G; De Strooper, Bart; Kopan, Raphael 2005. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental cell, 8 5, 677-88Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D 2004. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood, 104 10, 3097-105Nichols, Amy M; Pan, Yonghua; Herreman, An; Hadland, Brandon K; De Strooper, Bart; Kopan, Raphael; Huppert, Stacey S 2004. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000), 40 1, 40-4