Education/CredentialsMD, PhD: Huazhong University of Science and Technology (Clinical Medicine) Contact Information Email zhaofe@ucmail.uc.edu Peer Reviewed Publications Li, Jian; Li, Dayong; Zhao, Fujie; Wang, Yadong; Yao, Hongmin; Wu, Yin; An, Junqing; Liu, Zhixue; Ding, Ye; Zou, Ming-Hui 2026. Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis. Nature communications, 17 1, 1836Li, Feifei; Kumar, Sandeep; Pokutta-Paskaleva, Anastassia; Kang, Dong-Won; Kim, Chanwoo; Raykin, Julia; Omojola, Victor; Hoffmann, Carson; Zhao, Fujie; Teichmann, Maiko; Park, Christian; In Baek, Kyung; Sanchez Marrero, Gloriani; Ma, Jing; Yanagisawa, Hiromi; Leask, Andrew; Timmins, Lucas; Cui, Xiangqin; Sutliff, Roy; Gleason, Rudy L; Jo, Hanjoong; Brewster, Luke P 2025. Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis. Matrix biology : journal of the International Society for Matrix Biology, 136 , 102-110Zhao, Fujie; Li, Feifei; Sedaghati, Farbod; Dong, Hai; Kumar, Sandeep; Foster, Dennis Gene; Otto, Jim; Giangiacomo, Dana; Timmins, Lucas H; Sasaki, Maiko; Marrero, Gloriani Sanchez; Baek, Kyung In; Tu, Michael; Peprah, Sandra; Cui, Xiangqin; Lawson, Jeffrey H; Gleason, Rudolph L; Jo, Hanjoong; Brewster, Luke 2025. Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model. JVS-vascular science, 6 , 100394Cai, Zhaohua; Satyanarayana, Ganesh; Song, Ping; Zhao, Fujie; You, Shaojin; Liu, Zhixue; Mu, Jing; Ding, Ye; He, Ben; Zou, Ming-Hui 2024. Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo. Cardiovascular research, 120 14, 1780-1793Cai, Zhaohua; You, Shaojin; Liu, Zhixue; Song, Ping; Zhao, Fujie; An, Junqing; Ding, Ye; He, Ben; Zou, Ming-Hui 2024. Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo. Cell death & disease, 15 3, 212Li, Jian; Yao, Hongmin; Zhao, Fujie; An, Junqing; Wang, Qilong; Mu, Jing; Liu, Zhixue; Zou, Ming-Hui; Xie, Zhonglin 2024. Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue. Autophagy, 20 3, 629-644Meng, Zhijun; Liang, Bin; Wu, Yalin; Liu, Caihong; Wang, Han; Du, Yunhui; Gan, Lu; Gao, Erhe; Lau, Wayne B; Christopher, Theodore A; Lopez, Bernard L; Koch, Walter J; Ma, Xinliang; Zhao, Fujie; Wang, Yajing; Zhao, Jianli 2023. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice. Journal of molecular and cellular cardiology, 182 , 1-14Wu, Yang; Zhao, Fujie; Sure, Venkata N; Ibrahim, Abdulgafar; Yu, Changjiang; Carr, Sean M; Song, Ping 2023. Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function. Cells, 12 3, Zhao, Jianli; Xie, Yaoli; Meng, Zhijun; Liu, Caihong; Wu, Yalin; Zhao, Fujie; Ma, Xinliang; Christopher, Theodore A; Lopez, Bernard J; Wang, Yajing 2023. COVID-19 and cardiovascular complications: updates of emergency medicine. Emergency and critical care medicine, 3 3, 104-114Zhao, Fujie; Satyanarayana, Ganesh; Zhang, Zheng; Zhao, Jianli; Ma, Xin-Liang; Wang, Yajing 2022. Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease. Cells, 11 13, Wu, Yang; Johnson, Gem; Zhao, Fujie; Wu, Yin; Zhao, Guojun; Brown, Andrew; You, Shaojin; Zou, Ming-Hui; Song, Ping 2021. Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models. International journal of molecular sciences, 22 15, Zhao, Fujie; Zou, Ming-Hui 2021. Role of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease. Frontiers in cardiovascular medicine, 8 , 749756Zhaohua Cai, Ping Song, Shaojin You, Zhixue Liu, Fujie Zhao, Jing Mu, Xiaoxu Zheng, Ye Ding, Lei Xiao, Tharmarajan Ramprasath, Yu Qiu, Ben He, Ming-Hui Zou 2020. Lkb1 is a master regulator of VSMC fate and function in mice bioRxiv, , 2020.12. 12.422410Wu, Lujin; Zhao, Fujie; Dai, Meiyan; Li, Huaping; Chen, Chen; Nie, Jiali; Wang, Peihua; Wang, Dao Wen 2017. P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice. Hypertension (Dallas, Tex. : 1979), 70 4, 759-769Chen, Peng; Chaugai, Sandip; Zhao, Fujie; Wang, Dao Wen 2015. Cardioprotective Effect of Thiazide-Like Diuretics: A Meta-Analysis. American journal of hypertension, 28 12, 1453-63Zhao, Fujie; Chaugai, Sandip; Chen, Peng; Wang, Yan; Wang, Dao Wen 2014. Effect of nicorandil in patients with heart failure: a systematic review and meta-analysis. Cardiovascular therapeutics, 32 6, 283-96Zhao, F; Huang, X; Hou, X; Deng, Y; Wu, M; Guan, F; Liu, W; Li, Y; Lei, J 2013. Schistosoma japonicum: susceptibility of neonate mice born to infected and noninfected mothers following subsequent challenge. Parasite immunology, 35 5-6, 157-63
Peer Reviewed Publications Li, Jian; Li, Dayong; Zhao, Fujie; Wang, Yadong; Yao, Hongmin; Wu, Yin; An, Junqing; Liu, Zhixue; Ding, Ye; Zou, Ming-Hui 2026. Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis. Nature communications, 17 1, 1836Li, Feifei; Kumar, Sandeep; Pokutta-Paskaleva, Anastassia; Kang, Dong-Won; Kim, Chanwoo; Raykin, Julia; Omojola, Victor; Hoffmann, Carson; Zhao, Fujie; Teichmann, Maiko; Park, Christian; In Baek, Kyung; Sanchez Marrero, Gloriani; Ma, Jing; Yanagisawa, Hiromi; Leask, Andrew; Timmins, Lucas; Cui, Xiangqin; Sutliff, Roy; Gleason, Rudy L; Jo, Hanjoong; Brewster, Luke P 2025. Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis. Matrix biology : journal of the International Society for Matrix Biology, 136 , 102-110Zhao, Fujie; Li, Feifei; Sedaghati, Farbod; Dong, Hai; Kumar, Sandeep; Foster, Dennis Gene; Otto, Jim; Giangiacomo, Dana; Timmins, Lucas H; Sasaki, Maiko; Marrero, Gloriani Sanchez; Baek, Kyung In; Tu, Michael; Peprah, Sandra; Cui, Xiangqin; Lawson, Jeffrey H; Gleason, Rudolph L; Jo, Hanjoong; Brewster, Luke 2025. Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model. JVS-vascular science, 6 , 100394Cai, Zhaohua; Satyanarayana, Ganesh; Song, Ping; Zhao, Fujie; You, Shaojin; Liu, Zhixue; Mu, Jing; Ding, Ye; He, Ben; Zou, Ming-Hui 2024. Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo. Cardiovascular research, 120 14, 1780-1793Cai, Zhaohua; You, Shaojin; Liu, Zhixue; Song, Ping; Zhao, Fujie; An, Junqing; Ding, Ye; He, Ben; Zou, Ming-Hui 2024. Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo. Cell death & disease, 15 3, 212Li, Jian; Yao, Hongmin; Zhao, Fujie; An, Junqing; Wang, Qilong; Mu, Jing; Liu, Zhixue; Zou, Ming-Hui; Xie, Zhonglin 2024. Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue. Autophagy, 20 3, 629-644Meng, Zhijun; Liang, Bin; Wu, Yalin; Liu, Caihong; Wang, Han; Du, Yunhui; Gan, Lu; Gao, Erhe; Lau, Wayne B; Christopher, Theodore A; Lopez, Bernard L; Koch, Walter J; Ma, Xinliang; Zhao, Fujie; Wang, Yajing; Zhao, Jianli 2023. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice. Journal of molecular and cellular cardiology, 182 , 1-14Wu, Yang; Zhao, Fujie; Sure, Venkata N; Ibrahim, Abdulgafar; Yu, Changjiang; Carr, Sean M; Song, Ping 2023. Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function. Cells, 12 3, Zhao, Jianli; Xie, Yaoli; Meng, Zhijun; Liu, Caihong; Wu, Yalin; Zhao, Fujie; Ma, Xinliang; Christopher, Theodore A; Lopez, Bernard J; Wang, Yajing 2023. COVID-19 and cardiovascular complications: updates of emergency medicine. Emergency and critical care medicine, 3 3, 104-114Zhao, Fujie; Satyanarayana, Ganesh; Zhang, Zheng; Zhao, Jianli; Ma, Xin-Liang; Wang, Yajing 2022. Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease. Cells, 11 13, Wu, Yang; Johnson, Gem; Zhao, Fujie; Wu, Yin; Zhao, Guojun; Brown, Andrew; You, Shaojin; Zou, Ming-Hui; Song, Ping 2021. Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models. International journal of molecular sciences, 22 15, Zhao, Fujie; Zou, Ming-Hui 2021. Role of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease. Frontiers in cardiovascular medicine, 8 , 749756Zhaohua Cai, Ping Song, Shaojin You, Zhixue Liu, Fujie Zhao, Jing Mu, Xiaoxu Zheng, Ye Ding, Lei Xiao, Tharmarajan Ramprasath, Yu Qiu, Ben He, Ming-Hui Zou 2020. Lkb1 is a master regulator of VSMC fate and function in mice bioRxiv, , 2020.12. 12.422410Wu, Lujin; Zhao, Fujie; Dai, Meiyan; Li, Huaping; Chen, Chen; Nie, Jiali; Wang, Peihua; Wang, Dao Wen 2017. P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice. Hypertension (Dallas, Tex. : 1979), 70 4, 759-769Chen, Peng; Chaugai, Sandip; Zhao, Fujie; Wang, Dao Wen 2015. Cardioprotective Effect of Thiazide-Like Diuretics: A Meta-Analysis. American journal of hypertension, 28 12, 1453-63Zhao, Fujie; Chaugai, Sandip; Chen, Peng; Wang, Yan; Wang, Dao Wen 2014. Effect of nicorandil in patients with heart failure: a systematic review and meta-analysis. Cardiovascular therapeutics, 32 6, 283-96Zhao, F; Huang, X; Hou, X; Deng, Y; Wu, M; Guan, F; Liu, W; Li, Y; Lei, J 2013. Schistosoma japonicum: susceptibility of neonate mice born to infected and noninfected mothers following subsequent challenge. Parasite immunology, 35 5-6, 157-63
Li, Jian; Li, Dayong; Zhao, Fujie; Wang, Yadong; Yao, Hongmin; Wu, Yin; An, Junqing; Liu, Zhixue; Ding, Ye; Zou, Ming-Hui 2026. Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis. Nature communications, 17 1, 1836Li, Feifei; Kumar, Sandeep; Pokutta-Paskaleva, Anastassia; Kang, Dong-Won; Kim, Chanwoo; Raykin, Julia; Omojola, Victor; Hoffmann, Carson; Zhao, Fujie; Teichmann, Maiko; Park, Christian; In Baek, Kyung; Sanchez Marrero, Gloriani; Ma, Jing; Yanagisawa, Hiromi; Leask, Andrew; Timmins, Lucas; Cui, Xiangqin; Sutliff, Roy; Gleason, Rudy L; Jo, Hanjoong; Brewster, Luke P 2025. Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis. Matrix biology : journal of the International Society for Matrix Biology, 136 , 102-110Zhao, Fujie; Li, Feifei; Sedaghati, Farbod; Dong, Hai; Kumar, Sandeep; Foster, Dennis Gene; Otto, Jim; Giangiacomo, Dana; Timmins, Lucas H; Sasaki, Maiko; Marrero, Gloriani Sanchez; Baek, Kyung In; Tu, Michael; Peprah, Sandra; Cui, Xiangqin; Lawson, Jeffrey H; Gleason, Rudolph L; Jo, Hanjoong; Brewster, Luke 2025. Piezo-type mechanosensitive ion channel component 1 (PIEZO1) is upregulated in peripheral arterial disease (PAD) and a novel murine PAD model. JVS-vascular science, 6 , 100394Cai, Zhaohua; Satyanarayana, Ganesh; Song, Ping; Zhao, Fujie; You, Shaojin; Liu, Zhixue; Mu, Jing; Ding, Ye; He, Ben; Zou, Ming-Hui 2024. Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo. Cardiovascular research, 120 14, 1780-1793Cai, Zhaohua; You, Shaojin; Liu, Zhixue; Song, Ping; Zhao, Fujie; An, Junqing; Ding, Ye; He, Ben; Zou, Ming-Hui 2024. Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo. Cell death & disease, 15 3, 212Li, Jian; Yao, Hongmin; Zhao, Fujie; An, Junqing; Wang, Qilong; Mu, Jing; Liu, Zhixue; Zou, Ming-Hui; Xie, Zhonglin 2024. Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue. Autophagy, 20 3, 629-644Meng, Zhijun; Liang, Bin; Wu, Yalin; Liu, Caihong; Wang, Han; Du, Yunhui; Gan, Lu; Gao, Erhe; Lau, Wayne B; Christopher, Theodore A; Lopez, Bernard L; Koch, Walter J; Ma, Xinliang; Zhao, Fujie; Wang, Yajing; Zhao, Jianli 2023. Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice. Journal of molecular and cellular cardiology, 182 , 1-14Wu, Yang; Zhao, Fujie; Sure, Venkata N; Ibrahim, Abdulgafar; Yu, Changjiang; Carr, Sean M; Song, Ping 2023. Human ApoE2 Endows Stronger Contractility in Rat Cardiomyocytes Enhancing Heart Function. Cells, 12 3, Zhao, Jianli; Xie, Yaoli; Meng, Zhijun; Liu, Caihong; Wu, Yalin; Zhao, Fujie; Ma, Xinliang; Christopher, Theodore A; Lopez, Bernard J; Wang, Yajing 2023. COVID-19 and cardiovascular complications: updates of emergency medicine. Emergency and critical care medicine, 3 3, 104-114Zhao, Fujie; Satyanarayana, Ganesh; Zhang, Zheng; Zhao, Jianli; Ma, Xin-Liang; Wang, Yajing 2022. Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease. Cells, 11 13, Wu, Yang; Johnson, Gem; Zhao, Fujie; Wu, Yin; Zhao, Guojun; Brown, Andrew; You, Shaojin; Zou, Ming-Hui; Song, Ping 2021. Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models. International journal of molecular sciences, 22 15, Zhao, Fujie; Zou, Ming-Hui 2021. Role of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease. Frontiers in cardiovascular medicine, 8 , 749756Zhaohua Cai, Ping Song, Shaojin You, Zhixue Liu, Fujie Zhao, Jing Mu, Xiaoxu Zheng, Ye Ding, Lei Xiao, Tharmarajan Ramprasath, Yu Qiu, Ben He, Ming-Hui Zou 2020. Lkb1 is a master regulator of VSMC fate and function in mice bioRxiv, , 2020.12. 12.422410Wu, Lujin; Zhao, Fujie; Dai, Meiyan; Li, Huaping; Chen, Chen; Nie, Jiali; Wang, Peihua; Wang, Dao Wen 2017. P2y12 Receptor Promotes Pressure Overload-Induced Cardiac Remodeling via Platelet-Driven Inflammation in Mice. Hypertension (Dallas, Tex. : 1979), 70 4, 759-769Chen, Peng; Chaugai, Sandip; Zhao, Fujie; Wang, Dao Wen 2015. Cardioprotective Effect of Thiazide-Like Diuretics: A Meta-Analysis. American journal of hypertension, 28 12, 1453-63Zhao, Fujie; Chaugai, Sandip; Chen, Peng; Wang, Yan; Wang, Dao Wen 2014. Effect of nicorandil in patients with heart failure: a systematic review and meta-analysis. Cardiovascular therapeutics, 32 6, 283-96Zhao, F; Huang, X; Hou, X; Deng, Y; Wu, M; Guan, F; Liu, W; Li, Y; Lei, J 2013. Schistosoma japonicum: susceptibility of neonate mice born to infected and noninfected mothers following subsequent challenge. Parasite immunology, 35 5-6, 157-63