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Christopher D. Koch

Associate Professor of Clinical

Pathology & Laboratory Medicine | College of Medicine

Education/Credentials
  • Fellowship: Yale University, Yale-New Haven Hospital (Clinical Chemistry)
  • PhD: Cleveland State University (Clinical-Bioanalytical Chemistry)
  • BS: University of Minnesota - Twin Cities (Biochemistry; Genetics and Cell Development)
Contact Information

Peer Reviewed Publications

de Groot, Rens; Folgado, Patricia Badía; Yamamoto, Kazuhiro; Martin, Daniel R; Koch, Christopher D; Debruin, Danielle; Blagg, Sophie; Minns, Alexander F; Bhutada, Sumit; Ahnström, Josefin; Larkin, Jonathan; Aspberg, Anders; Önnerfjord, Patrik; Apte, Suneel S; Santamaria, Salvatore 2025. Cleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis and other forms of degenerative joint disease. Matrix biology : journal of the International Society for Matrix Biology, 135 , 106-124

Fatica, Erica M; Koch, Christopher D 2025. Fostering Research Collaborations as an Early Career Clinical Laboratory Director. The journal of applied laboratory medicine, 10 3, 775-777

Westöö, Christian; Mutgan, Ayse Ceren; van der Have, Oscar; Mead, Timothy J; Ahmed, Salaheldin; Lampei, Elna; Koch, Christopher D; Norvik, Christian; Aspberg, Anders; Bech, Martin; Peruzzi, Niccolò; Brunnström, Hans; Kwapiszewska, Grazyna; Rådegran, Göran; Apte, Suneel S; Tran-Lundmark, Karin 2025. Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 73 3-4, 129-145

Bunch, Dustin R; Koch, Christopher D 2024. Reference Intervals: A Hoffmann Method Improvement? The journal of applied laboratory medicine, 9 2, 197-200

Noguez, Jaime H; Koch, Christopher D 2023. Bridging the gap: The critical role of laboratory developed tests in clinical toxicology. Journal of mass spectrometry and advances in the clinical lab, 28 , 70-74

Vera, Michael A; Koch, Christopher D; El-Khoury, Joe M 2023. Resolving icteric interference by a novel photoisomerization device: Bilibox. Clinical biochemistry, 115 , 112-115

Koch, Christopher D; Vera, Michael A; El-Khoury, Joe M 2022. Rapid serum clot tubes reduce haemolysis due to pneumatic tube transport. Journal of clinical pathology, 75 9, 643-645

Vera, Michael A; Koch, Christopher D; Liapakis, AnnMarie; Lim, Joseph K; El-Khoury, Joe M 2022. The ALT upper reference interval debate: Blame it on the alcohol. Clinica chimica acta; international journal of clinical chemistry, 526 , 62-65

Binns, Thomas C; Koch, Christopher D; Durant, Thomas J S; El-Khoury, Joe M 2021. CO-Oximetry Interference in a Patient with Dyspnea Refractory to Oxygen Therapy. The journal of applied laboratory medicine, 6 6, 1671-1676

Koch, Christopher D; Paulson, Nathan; Vera, Michael A; Loza, Andrew; El-Khoury, Joe M 2021. Elevated Lipemia Index in Dark-Brown Plasma from a Bronze Baby. Clinical chemistry, 67 2, 447-448

Koch, Christopher D; Vera, Michael A; Messina, Jasmine; Price, Nathan; Durant, Thomas J S; El-Khoury, Joe M 2021. Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate. Clinica chimica acta; international journal of clinical chemistry, 520 , 63-66

Koch, Christopher D; Vera, Michael A; Paulson, Nathan; El-Khoury, Joe M 2021. The case of the hyponatremias. Clinica chimica acta; international journal of clinical chemistry, 520 , 76-77

Li, Philippa; Koch, Christopher D; El-Khoury, Joe M 2021. Increased Lipemia Index in a Dark Green Sample from a Patient after Heart Transplant. Clinical chemistry, 67 11, 1575-1576

Li, Philippa; Koch, Christopher D; El-Khoury, Joe M 2021. Perimenopausal woman with elevated serum hCG and abdominal pain. Clinica chimica acta; international journal of clinical chemistry, 522 , 141-143

Martin, Daniel R; Santamaria, Salvatore; Koch, Christopher D; Ahnström, Josefin; Apte, Suneel S 2021. Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach. Journal of proteomics, 249 , 104358

Vera, Michael A; Koch, Christopher D; Kavsak, Peter A; El-Khoury, Joe M 2021. Determination of 97.5th and 99th percentile upper reference limits for heart-type fatty acid-binding protein (H-FABP) in a US population. Clinica chimica acta; international journal of clinical chemistry, 523 , 397-401

Koch, Christopher D; El-Khoury, Joe M 2020. New Sampson Low-Density Lipoprotein Equation: Better Than Friedewald and Martin-Hopkins. Clinical chemistry, 66 8, 1120-1121

Koch, Christopher D; Lee, Chan Mi; Apte, Suneel S 2020. Aggrecan in Cardiovascular Development and Disease. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 68 11, 777-795

Koch, Christopher D; Xu, Liang; Curtis, Susanna A; Roberts, John D; Bunch, Dustin R; El-Khoury, Joe M 2020. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica chimica acta; international journal of clinical chemistry, 510 , 515-521

Cikach, Frank S; Koch, Christopher D; Mead, Timothy J; Galatioto, Josephine; Willard, Belinda B; Emerton, Kelly B; Eagleton, Matthew J; Blackstone, Eugene H; Ramirez, Francesco; Roselli, Eric E; Apte, Suneel S 2018. Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection. JCI insight, 3 5,

Gueye, Ndeye-Aicha; Mead, Timothy J; Koch, Christopher D; Biscotti, Charles V; Falcone, Tommaso; Apte, Suneel S 2017. Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma. The Journal of clinical endocrinology and metabolism, 102 5, 1631-1641

Tolan, Nicole V; Wockenfus, Amy M; Koch, Christopher D; Crews, Bridgit O; Dietzen, Dennis J; Karon, Brad S 2017. Analytical performance of three whole blood point-of-care lactate devices compared to plasma lactate comparison methods and a flow-injection mass spectrometry method. Clinical biochemistry, 50 4-5, 168-173

Geoghegan, Pierce; Koch, Christopher D; Wockenfus, Amy M; Harrison, Andrew M; Dong, Yue; Kashani, Kianoush B; Karon, Brad S 2015. Agreement between whole blood and plasma sodium measurements in profound hyponatremia. Clinical biochemistry, 48 7-8, 525-8

Karon, Brad S; Tolan, Nicole V; Koch, Christopher D; Wockenfus, Amy M; Miller, Randall S; Lingineni, Ravi K; Pruthi, Rajiv K; Chen, Dong; Jaffe, Allan S 2014. Precision and reliability of 5 platelet function tests in healthy volunteers and donors on daily antiplatelet agent therapy. Clinical chemistry, 60 12, 1524-31

Tange, Julie I; Grill, Diane; Koch, Christopher D; Ybabez, Roxanne J; Krekelberg, Benjamin J; Fylling, Kara A; Wiese, Cynthia R; Baumann, Nikola A; Block, Darci R; Karon, Brad S; Chen, Dong; Pruthi, Rajiv K 2014. Local verification and assignment of mean normal prothrombin time and International Sensitivity Index values across various instruments: recent experience and outcome from North America. Seminars in thrombosis and hemostasis, 40 1, 115-20

Block, Darci R; Wockenfus, Amy M; Koch, Christopher D; Karon, Brad S 2013. Analytical performance of three point of care methods for pleural fluid pH analysis. Clinical biochemistry, 46 12, 1139-1141

Gilman, Elizabeth A; Koch, Christopher D; Santrach, Paula J; Schears, Gregory J; Karon, Brad S 2013. Fresh and citrated whole-blood specimens can produce different thromboelastography results in patients on extracorporeal membrane oxygenation. American journal of clinical pathology, 140 2, 165-9

Wockenfus, Amy M; Koch, Christopher D; Conlon, Patricia M; Sorensen, Linda D; Cambern, Kari L; Chihak, Amy J; Zmolek, Julie A; Petersen, Amy E; Burns, Bradley E; Lieske, John C; Karon, Brad S 2013. Discordance between urine pH measured by dipstick and pH meter: implications for methotrexate administration protocols. Clinical biochemistry, 46 1-2, 152-4

Koch, Christopher D; Wockenfus, Amy M; Saenger, Amy K; Jaffe, Allan S; Karon, Brad S 2012. BD rapid serum tubes reduce false positive plasma troponin T results on the Roche Cobas e411 analyzer. Clinical biochemistry, 45 10-11, 842-4

Jaben, Elizabeth A; Koch, Christopher D; Karon, Brad S 2011. Lipid emulsion solution: A novel cause of hemolysis in serum and plasma blood samples. Clinical biochemistry, 44 2-3, 254-6

Karon, Brad S; Koch, Christopher D; Wockenfus, Amy M; Brown, Julie K 2009. Accuracy of whole blood glucose measurement when venous catheter blood samples are used on glucose meters. Diabetes technology & therapeutics, 11 12, 819-25