Conforti Lab

Selected Publications:

Khodoun M, Chimote AA, Ilyas FZ, Duncan HJ, Moncrieffe H, Kant KS, Conforti L. Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus Sci Adv. 2020 Nov 18;6(47):eabd1471. doi: 10.1126/sciadv.abd1471.

Newton, H.S., Gawali, V.S. , Chimote, A.A. , Lehn, M.A., Palackdharry, S.M., Hinrichs, B.H., Jandarov, R., Hildeman, D., Janssen, E.M., Wise-Draper, T.M., & Conforti, L. PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer Journal for Immunotherapy of Cancer 2020; 8:e000844. doi: 10.1136/jitc-2020-000844

Chimote, A.A., Gawali, V.S., Newton, H.S., Wise-Draper, T.M., & Conforti, L. A compartmentalized reduction in membrane-proximal calmodulin reduces the immune surveillance capabilities of CD8+ T cells in head and neck cancer Frontiers in Pharmacology 2020 Feb 28;11:143. doi: 10.3389/fphar.2020.00143. eCollection

Chimote A.A., Balajthy A., Arnold M. J., Newton H., Hajdu P., Qualtieri J., Wise-Draper T. and Conforti L. A defect in KCa3.1 channel activity limits the ability of CD8⁺ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Sci Signal. 2018 Apr 24;11(527). pii: eaaq1616. doi: 10.1126/scisignal.aaq1616. PMID: 29692361

Chimote A.A., Hajdu P., Sfyris A.M., Gleich B., Wise-Draper T., Casper K. and Conforti L.: Kv1.3 channels mark functional competent CD8+ tumor infiltrating lymphocytes in head and neck cancer. Cancer Res January 1 2017, 77 (1): 53-61; DOI:10.1158/0008-5472.CAN-16-2372.

Chimote AA, Hajdu P, Kucher V, Boiko N, Kuras Z, Szilagyi O, Yun YH, Conforti L.: Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. J Immunol. 2013 Dec 15;191(12):6273-80. doi: 10.4049/jimmunol.1300702. Epub 2013 Nov 13. PubMed PMID: 24227782; PubMed Central PMCID: PMC4415878.

Hajdu P., Chimote A.A., Thompson T., Koo Y., Yun Y-H. and Conforti L.: Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials 34, pp. 10249-10257, 2013. DOI information: 10.1016/j.biomaterials.2013.09.019. PMID: 24075407 PMCID: PMC3900865.

Kuras Z., Yun Y-H., Chimote A. A., Neumeier L., Conforti L.: KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PLoS ONE 7(8): e43859, 2012. doi:10.1371/journal.pone.0043859. PMID: 22952790 PMCID: PMC3428288

Nicolaou S., Szigligeti P., Duncan H., Neumeier L., Molleran Lee S., A.B. Mongey, Kant S. K., Filipovich A. H. and L. Conforti: Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in Systemic Lupus Erythematosus. J. Immunol. 179(1):346-56, 2007.

Conforti L., Petrovic M., Mohammad D., Lee S., Ma Q., Barone S. and Filipovich A. H.: Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation. J. Immunol. 170: 695-702, 2003.