Publications

Complete list of our publications, please visit: Perez-Tilve Publications (Pubmed)

2025

Douros, Jonathan D; Novikoff, Aaron; DuBois, Barent; Rohlfs, Rebecca; Mokrosinski, Jacek; Hogendorf, Wouter F J; Augustin, Robert; Merkestein, Myrte; Egaa Martini, Lene Brandt; Linderoth, Lars; Gerrard, Elliot; Kodra, Janos Tibor; Norlin, Jenny; Roed, Nikolaj Kulahin; Oldenburger, Anouk; Mowery, Stephanie A; Waldhoer, Maria; Perez-Tilve, Diego; Finan, Brian; Reedtz-Runge, Steffen; Müller, Timo D; Knerr, Patrick J 2025. A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice. Molecular metabolism, 100 , 102124

Gonzalez, Hanna; Cheng, Lei; Chang, Qing; Gold, Paul E; Perez-Tilve, Diego; Wang, YanYan 2025. Overexpression of the short isoform of the dopamine D2 receptor causes diet-induced obesity and hyperglycemia in mice. Journal of neuroendocrinology, 37 8, e70042

Finan, Brian; Douros, Jonathan D; Goldwater, Ronald; Hansen, Ann Maria Kruse; Hjerpsted, Julie B; Hjøllund, Karina Rahr; Kankam, Martin K; Knerr, Patrick J; Konkar, Anish; Mowery, Stephanie A; Müller, Timo D; Nielsen, John Rømer; Nygård, Sune Boris; Perez-Tilve, Diego; Raun, Kirsten; Yang, Bin; Tschöp, Matthias H; DiMarchi, Richard D 2025. A once-daily GLP-1/GIP/glucagon receptor tri-agonist (NN1706) lowers body weight in rodents, monkeys and humans. Molecular metabolism, 96 , 102129

Zandvakili, Inuk; Perez-Tilve, Diego 2025. The unexpected role of GIP in transforming obesity treatment. Trends in endocrinology and metabolism: TEM, 36 4, 330-338

Espinal Abreu, Valerie; Barnes, Rachel; Borra, Vishnupriya; Schurdak, Jennifer; Perez-Tilve, Diego 2025. Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons. Molecular metabolism, 91 , 102079

2024

Zaykov, Alexander N; Gelfanov, Vasily M; Tagmose, Tina M; Demozay, Damien; Manfè, Valentina; Rohlfs, Rebecca; Rivir, Marita; Perez-Tilve, Diego; Finan, Brian; DiMarchi, Richard D 2024. Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation. RSC chemical biology, 5 8, 763-775

Kusminski, Christine M; Perez-Tilve, Diego; Müller, Timo D; DiMarchi, Richard D; Tschöp, Matthias H; Scherer, Philipp E 2024. Transforming obesity: The advancement of multi-receptor drugs. Cell, 187 15, 3829-3853

Kizilkaya, Hüsün S; Sørensen, Kimmie V; Madsen, Jakob S; Lindquist, Peter; Douros, Jonathan D; Bork-Jensen, Jette; Berghella, Alessandro; Gerlach, Peter A; Gasbjerg, Lærke S; Mokrosiński, Jacek; Mowery, Stephanie A; Knerr, Patrick J; Finan, Brian; Campbell, Jonathan E; D'Alessio, David A; Perez-Tilve, Diego; Faas, Felix; Mathiasen, Signe; Rungby, Jørgen; Sørensen, Henrik T; Vaag, Allan; Nielsen, Jens S; Holm, Jens-Christian; Lauenborg, Jeannet; Damm, Peter; Pedersen, Oluf; Linneberg, Allan; Hartmann, Bolette; Holst, Jens J; Hansen, Torben; Wright, Shane C; Lauschke, Volker M; Grarup, Niels; Hauser, Alexander S; Rosenkilde, Mette M 2024. Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes. Nature metabolism, 6 7, 1268-1281

Shankar, Kripa; Metzger, Nathan P; Lawrence, Connor; Gupta, Deepali; Osborne-Lawrence, Sherri; Varshney, Salil; Singh, Omprakash; Richard, Corine P; Zaykov, Alexander N; Rolfts, Rebecca; DuBois, Barent N; Perez-Tilve, Diego; Mani, Bharath K; Hammer, Suntrea T G; Zigman, Jeffrey M 2024. A long-acting LEAP2 analog reduces hepatic steatosis and inflammation and causes marked weight loss in mice. Molecular metabolism, 84 , 101950

2023

El, Kimberley; Douros, Jonathan D; Willard, Francis S; Novikoff, Aaron; Sargsyan, Ashot; Perez-Tilve, Diego; Wainscott, David B; Yang, Bin; Chen, Alex; Wothe, Donald; Coupland, Callum; Tschöp, Mattias H; Finan, Brian; D'Alessio, David A; Sloop, Kyle W; Müller, Timo D; Campbell, Jonathan E 2023. The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nature metabolism, 5 6, 945-954

2022

Yang, Bin; Gelfanov, Vasily M; El, Kimberley; Chen, Alex; Rohlfs, Rebecca; DuBois, Barent; Kruse Hansen, Ann Maria; Perez-Tilve, Diego; Knerr, Patrick J; D'Alessio, David; Campbell, Jonathan E; Douros, Jonathan D; Finan, Brian 2022. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. Molecular metabolism, 66 , 101638

Knerr, Patrick J; Mowery, Stephanie A; Douros, Jonathan D; Premdjee, Bhavesh; Hjøllund, Karina Rahr; He, Yantao; Kruse Hansen, Ann Maria; Olsen, Anette K; Perez-Tilve, Diego; DiMarchi, Richard D; Finan, Brian 2022. Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice. Molecular metabolism, 63 , 101533

Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Baugé, Eric; Campbell, Jonathan E; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M; Knerr, Patrick J; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D; Tschöp, Matthias H; Finan, Brian; Müller, Timo D 2022. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature metabolism, 4 8, 1071-1083

Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego 2022. Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons. Neuroendocrinology, 112 3, 287-297