Publications

Detailed list of all publications

• Myocardial Krüppel-Like Factor 5 Abundance Holds Prognostic Value for Myocardial Recovery of Patients With Heart Failure Following Mechanical Unloading and Circulatory Support. Georgios Siokatas, Rana Hamouche, Eleni Maneta, Craig Selzman, Konstantinos E Hatzistergos, Stavros G Drakos, Konstantinos Drosatos. J Am Heart Assoc. 2024 Aug 20;13(16):e035661
• KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Ioannis D Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J Koch, Ira J Goldberg, Vincent W Yang, Agnieszka B Bialkowska, Georgios Kararigas, Konstantinos Drosatos. ​Circ Res 2021 Feb 5;128(3):335-357
• Cardiomyocyte Krüppel-Like Factor 5 Promotes De Novo Ceramide Biosynthesis and Contributes to Eccentric Remodeling in Ischemic Cardiomyopathy. ​Matthew Hoffman, Dimitra Palioura, Ioannis D Kyriazis, Maria Cimini, Rachit Badolia, Sudarsan Rajan, Erhe Gao, Nikolas Nikolaidis, P Christian Schulze, Ira J Goldberg, Raj Kishore, Vincent W Yang, Thomas D Bannister, Agnieszka B Bialkowska, Craig H Selzman, Stavros G Drakos, Konstantinos Drosatos. Circulation. 2021 Mar 16;143(11):1139-1156 
• B-type natriuretic peptide is upregulated by c-Jun N-terminal kinase and contributes to septic hypotension. Hoffman M, Kyriazis ID, Dimitriou A, Mishra SK, Koch WJ, Drosatos K. JCI Insight. 2020 Apr 23;5(8)
• Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice. Hoffman M, Kyriazis ID, Lucchese AM, de Lucia C, Piedepalumbo M, Bauer M, Schulze PC, Bonios MJ, Koch WJ, Drosatos K.  J Am Heart Assoc. 2019 May 21;8(10):e012260
• Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction. Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. JCI Insight. 2019.
• Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K. Biochem Biophys Acta Mol Basis Dis. 2019 Apr 26. pii:S0925-4439(19)30121-8
• Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K.  J Mol Cell Cardiol. 2019 Feb;127:232-245.
  
• Krüppel-like factors: Crippling and un-crippling metabolic pathways. ​Pollak NM, Hoffman M, Goldberg IJ, Drosatos K. JACC Basic Transl Sci. 2018 Feb;3(1):132-156
• Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function. Joseph LC, Kokkinaki D, Valenti MC, Kim GJ, Barca E, Tomar D, Hoffman NE, Subramanyam P, Colecraft HM, Hirano M, Ratner AJ, Madesh M, Drosatos K, Morrow JP.  JCI Insight. 2017 Sep 7;2(17)
• Circulation Research. 2016 Jan 22;118(2):241-53. Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function. Drosatos K, Pollak NM, Pol CJ, Ntziachristos P, Willecke F, Valenti MC, Trent CM, Hu Y, Guo S, Aifantis I, Goldberg IJ
  Our study was selected for the Editorial:
  The Relationship Between KLF5 and PPARα in the Heart: It’s Complicated