Recent Publications

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2024

• Talari, Noble Kumar; Mattam, Ushodaya; Kaminska, Dorota; Sotomayor-Rodriguez, Irene; Rahman, Afra P; Péterfy, Miklós; Pajukanta, Päivi; Pihlajamäki, Jussi; Chella Krishnan, Karthickeyan. (2024) Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis. iScience 27(5):109709.

2023

• Chella Krishnan, Karthickeyan. (2023) Gut Health: When diet meets genetics. eLife 12:e92714.

• Patel, Sanil; Sparman, Njeri ZR; Arneson, Douglas; Alvarsson, Alexandra; Santos, Luís C; Duesman, Samuel J; Centonze, Alessia; Hathaway, Ephraim; Ahn, In Sook; Diamante, Graciel; Cely, Ingrid; Cho, Chung Hwan; Talari, Noble Kumar; Rajbhandari, Abha K; Goedeke, Leigh; Wang, Peng; Butte, Atul J; Blanpain, Cédric; Chella Krishnan, Karthickeyan; Lusis, Aldons J; Stanley, Sarah A; Yang, Xia; Rajbhandari, Prashant. (2023) Mammary duct luminal epithelium controls adipocyte thermogenic programme. Nature 620, 192–199.

• Chella Krishnan, Karthickeyan*; El Hachem, Elie-Julien; Keller, Mark P; Patel, Sanjeet G; Carroll, Luke; Vegas, Alexis Diaz; Gerdes, Gyuricza Isabela; Light, Christine; Cao, Yang; Pan, Calvin; Kaczor-Urbanowicz, Karolina Elżbieta; Shravah, Varun; Anum, Diana; Pellegrini, Matteo; Lee, Chi Fung; Seldin, Marcus M; Rosenthal, Nadia A; Churchill, Gary A; Attie, Alan D; Parker, Benjamin; James, David E; Lusis, Aldons J. (2023) Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. eLife 12:e82619.
  * co-corresponding author.

2022

• Cao, Yang; Vergnes, Laurent; Wang, Yu-Chen ; Pan, Calvin; Chella Krishnan, Karthickeyan; Moore, Timothy M; Rosa-Garrido, Manuel; Kimball, Todd H; Zhou, Zhiqiang; Charugundla, Sarada; Rau, Christoph D ; Seldin, Marcus M; Wang, Jessica; Wang, Yibin; Vondriska, Thomas M; Reue, Karen; Lusis, Aldons J. (2022) Sex differences in heart mitochondria regulate diastolic dysfunction. Nat Commun. 13(1):3850.

2021

• Chella Krishnan, Karthickeyan*; Vergnes, Laurent; Acín-Pérez, Rebeca; Stiles, Linsey; Shum, Michael; Ma, Lijiang; Mouisel, Etienne; Pan, Calvin; Moore, Timothy M; Péterfy, Miklós; Romanoski, Casey E; Reue, Karen; Björkegren, Johan LM; Laakso, Markku; Liesa, Marc; Lusis, Aldons J. (2021) Sex-Specific Genetic Regulation of Adipose Mitochondria and Metabolic Syndrome by Ndufv2. Nat Metab. 3(11):1552-1568.
  * co-corresponding author.
• Acín-Pérez, Rebeca; Petcherski, Anton; Veliova, Michaela; Benador, Ilan Y; Assali, Essam; Colleluori, Georgia; Cinti, Saverio; Brownstein, Alexandra J; Baghdasarian, Siyouneh; Livhits, Masha J; Yeh, Michael W; Chella Krishnan, Karthickeyan; Vergnes, Laurent; Winn, Nathan C; Padilla, Jaume; Liesa, Marc; Sacks, Harold S; Shirihai, Orian S. (2021) Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox Biol. 46:102087.
• Shum, Michael; Shintre, Chitra A; Althoff, Thorsten; Gutierrez, Vincent; Segawa, Mayuko; Saxberg, Alexandra D; Martinez, Melissa; Adamson, Roslin; Young, Margaret R; Faust, Belinda; Gharakhanian, Raffi; Su, Shi; Chella Krishnan, Karthickeyan; Mahdaviani, Kiana; Veliova, Michaela; Wolf, Dane M; Ngo, Jennifer; Nocito, Laura; Stiles, Linsey; Abramson, Jeff; Lusis, Aldons J; Hevener, Andrea L; Zoghbi, Maria E; Carpenter, Elisabeth P; Liesa, Marc. (2021)  ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity. Sci Transl Med. 13(594):eabd1869.
• Ferrara, Patrick J; Rong, Xin; Maschek, J Alan; Verkerke, Anthony Rp; Siripoksup, Piyarat; Song, Haowei; Green, Thomas D; Chella Krishnan, Karthickeyan; Johnson, Jordan M; Turk, John; Houmard, Joseph A; Lusis, Aldons J; Drummond, Micah J; McClung, Joseph M; Cox, James E; Shaikh, Saame Raza; Tontonoz, Peter; Holland, William L; Funai, Katsuhiko. (2021) Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. J Clin Invest. 131(8):135963. 
• Chella Krishnan, Karthickeyan*; Floyd, Raquel R; Sabir, Simon; Jayasekera, Dulshan W; Leon-Mimila, Paola V; Jones, Anthony E; Cortez, Angel A; Shravah, Varun; Péterfy, Miklós; Stiles, Linsey; Canizales-Quinteros, Samuel; Divakaruni, Ajit S; Huertas-Vazquez, Adriana; Lusis, Aldons J. (2021) Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 11(2):389-406.
  * co-corresponding author.
• Norheim, Frode; Chella Krishnan, Karthickeyan; Bjellaas, Thomas; Vergnes, Laurent; Pan, Calvin; Parks, Brian W; Meng, Yonghong; Lang, Jennifer; Ward, James A; Reue, Karen; Mehrabian, Margarete; Gundersen, Thomas E; Péterfy, Miklós; Dalen, Knut T; Drevon, Christian A; Hui, Simon T; Lusis, Aldons J; Seldin, Marcus M. (2021) Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Mol Syst Biol. 17(1):e9684.

2020

• Acín-Pérez, Rebeca; Iborra, Salvador; Martí-Mateos, Yolanda; Cook, Emma C L; Conde-Garrosa, Ruth; Petcherski, Anton; Muñoz, Mª Del Mar; Martínez de Mena, Raquel; Chella Krishnan, Karthickeyan; Jiménez, Concepción; Bolaños, Juan Pedro; Laakso, Markku; Lusis, Aldon J; Shirihai, Orian S; Sancho, David; Enríquez, José Antonio. (2020) Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nat Metab. 2(9):974-988.
• Santos, Luis C; Arneson, Douglas; Chella Krishnan, Karthickeyan; Ahn, In Sook; Diamante, Graciel; Cely, Ingrid; Butte, Atul J; Lusis, Aldons J; Yang, Xia; Rajbhandari, Prashant. (2020) Cold-associated mammokines preserve adipocyte identity. bioRxiv 2020.11.14.378687. DOI: https://doi.org/10.1101/2020.11.14.378687.
• Zhang, Guanglin; Byun, Hyae Ran; Ying, Zhe; Blencowe, Montgomery; Zhao, Yuqi; Hong, Jason; Shu, Le; Chella Krishnan, Karthickeyan; Gomez-Pinilla, Fernando; Yang, Xia. (2020) Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice. Biochim Biophys Acta Mol Basis Dis. 1866(1):165569.
• Nookala, Suba; Chella Krishnan, Karthickeyan; Mukundan, Santhosh; Kotb, Malak. (2020) Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections. Adv Exp Med Biol. 1294:151-166.