Hong-Sheng Wang Lab

Research Interests

The goal of my research is to define the impact of environmental contaminants on human heart health and heart disease. In particular, my research focuses on the cardiac toxicity of environmental chemicals in susceptible individuals and subpopulations with existing cardiac pathophysiological conditions. In past studies, we systematically examined the cardiac effects of bisphenol A (BPA) and its analogs and demonstrated that exposure to these chemicals has pro-arrhythmic and pro-hypertrophic toxicities in the heart. Our studies defined the signaling pathways, cellular and molecular mechanisms, and the basis of the sex-specificity and pharmacokinetic properties of the actions of these chemicals.

Current focuses of my lab include the cardiac toxicities of per- and polyfluoroalkyl substance (PFAS) and micro-nanoplastics. We address these questions using a combination of model systems including human iPSC-based preclinical cardiac models, small and large animal models, and human population analysis.